Tonic activity of Gα-gustducin regulates taste cell responsivity
نویسندگان
چکیده
منابع مشابه
Role of alpha-gustducin in palatal and fungiform taste buds
Page 219 Fish possess three types of olfactory sensory neurons, i.e., ciliated, microvillous, and crypt neurons, distributed throughout a single sensory epithelium. The former two cell populations are also present in mammals where they occur in various segregated olfactory subsystems. Whereas the ciliated neurons express odorant or trace amine-associated receptor genes, the microvillous neurons...
متن کاملFunctional expression of the taste specific G-protein, alpha-gustducin.
The taste-specific G-protein alpha-subunit, alpha-gustducin, was expressed using a baculovirus based system. alpha-Gustducin was demonstrated to be myristoylated and was also palmitoylated in insect larval cells. Recombinant alpha-gustducin was purified to homogeneity. Neither receptors nor effectors that interact with gustducin in taste are known. However, alpha-gustducin has a close structura...
متن کاملDirecting gene expression to gustducin-positive taste receptor cells.
We have demonstrated that an 8.4 kb segment (GUS(8.4)) from the upstream region of the mouse alpha-gustducin gene acts as a fully functional promoter to target lacZ transgene expression to the gustducin-positive subset of taste receptor cells (TRCs). The GUS(8. 4) promoter drove TRC expression of the beta-galactosidase marker at high levels and in a developmentally appropriate pattern. The gust...
متن کاملRole of the G-Protein Subunit -Gustducin in Taste Cell Responses to Bitter Stimuli
Many bitter stimuli are believed to bind to specific G-protein-coupled membrane receptors on taste cells. Despite the compelling evidence for its pivotal role in bitter taste sensation, a direct involvement of the G-protein subunit -gustducin in bitter taste transduction in taste cells has not been demonstrated in situ at the cellular level. We recorded activation of taste cells by bitter stimu...
متن کاملUmami Taste Responses Are Mediated by -Transducin and -Gustducin
Wei He,1* Keiko Yasumatsu,3* Vijaya Varadarajan,1 Ayako Yamada,3 Janis Lem,4 Yuzo Ninomiya,3 Robert F. Margolskee,2 and Sami Damak1 1Department of Physiology and Biophysics and 2Howard Hughes Medical Institute, The Mount Sinai School of Medicine, New York, New York 10029, 3Section of Oral Neuroscience, Kyushu University, Fukuoka 812-8582, Japan, and 4Department of Ophthalmology and Program in G...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2008
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2008.10.007